系统性炎症对神经发育的影响。
The Impact of Systemic Inflammation on Neurodevelopment.
机构信息
University of Virginia, Department of Medicine, Division of Infectious Diseases, MR4 Building Room 2115, Charlottesville, VA 22908, USA.
University of Virginia, Department of Medicine, Division of Infectious Diseases, MR4 Building Room 2115, Charlottesville, VA 22908, USA.
出版信息
Trends Mol Med. 2018 Sep;24(9):794-804. doi: 10.1016/j.molmed.2018.06.008. Epub 2018 Jul 11.
Abstract
Inflammatory mediators affect the brain during development. Neurodevelopmental disorders such as autism spectrum disorders, cognitive impairment, cerebral palsy, epilepsy, and schizophrenia have been linked to early life inflammation. Recent advances have shown the effects of systemic inflammation on children's neurodevelopment. We discuss the potential mechanisms by which inflammatory molecules can exert their effects on the developing brain and consider the roles of MHC class I molecules, the HPA axis, glial cells, and monoamine metabolism. Methods to prevent the effects of cytokine imbalance may lead to the development of new therapeutics for neuropsychiatric disorders. Future research should focus on identifying at-risk individuals and early effective interventions to prevent long-term neurodevelopmental disabilities.
摘要
炎症介质在发育过程中会影响大脑。自闭症谱系障碍、认知障碍、脑瘫、癫痫和精神分裂症等神经发育障碍与生命早期的炎症有关。最近的研究进展表明，全身炎症对儿童神经发育有影响。我们讨论了炎症分子对发育中大脑产生作用的潜在机制，并考虑了 MHC Ⅰ类分子、HPA 轴、神经胶质细胞和单胺代谢的作用。预防细胞因子失衡影响的方法可能会为神经精神疾病的治疗带来新的突破。未来的研究应集中在确定高危人群和早期有效的干预措施，以预防长期的神经发育障碍。
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