LncRNA 在调控炎症性疾病中的作用研究进展。
The research progress of LncRNA involved in the regulation of inflammatory diseases.
机构信息
Department of Clinical Laborotory, The Second Affiliated Hospital of Nanchang University, China; Jiangxi Province Key Laboratory of Laboratory Medicine, China.
Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, China.
出版信息
Mol Immunol. 2018 Sep;101:182-188. doi: 10.1016/j.molimm.2018.05.030. Epub 2018 Jul 4.
Long non-coding RNA (lncRNA)is a non-coding RNA which lacks a complete open reading frame(ORF) and plays an important role in biological processes such as cell proliferation,differentiation and apoptosis. At present,the expression of lncRNA has been found to be abnormal in inflammatory reaction and inflammatory diseases. It might be involved in the development and progression of inflammatory diseases by regulating the expression of multiple genes and activation of signaling pathways. This article overviewed the progress in study on relationship between lncRNA and inflammatory diseases.
长链非编码 RNA（lncRNA）是一种缺乏完整开放阅读框（ORF）的非编码 RNA，在细胞增殖、分化和凋亡等生物过程中发挥重要作用。目前，已经发现 lncRNA 在炎症反应和炎症性疾病中的表达异常，它可能通过调节多个基因的表达和信号通路的激活，参与炎症性疾病的发生和发展。本文综述了 lncRNA 与炎症性疾病关系的研究进展。
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