J Am Dent Assoc. 2018 Sep;149(9):778-786.e2. doi: 10.1016/j.adaj.2018.05.010. Epub 2018 Jul 12.
One of the adverse effects of orthodontic treatment is the appearance of white-spot lesions (WSLs) resulting from enamel demineralization. The objective of this systematic review was to investigate the effectiveness of remineralization therapies on WSLs after orthodontic treatment.
In this systematic review, the authors identified relevant articles listed in 5 databases-PubMed, the Cochrane Library, Scopus, Embase, and Web of Science-by using a combination of search terms referring to orthodontics, demineralization, and treatment. Ten articles on the efficacy of WSL remineralization therapies met the inclusion criteria.
Among the studies of remineralizing therapy, neither fluoride mouthrinses nor phosphopeptide toothpastes with or without fluoride had any positive effect in addition to oral hygiene maintenance with fluoride toothpaste. A 5% sodium fluoride varnish was the only therapy to show a statistically significant improvement compared with results in the control group. The authors found large variations in results among the studies reviewed because of the different methods used.
None of the treatments was capable of remineralizing WSLs. A 5% sodium fluoride varnish could improve remineralization of WSLs.
正畸治疗的不良反应之一是釉质脱矿导致的白斑（WSL）的出现。本系统评价的目的是研究正畸治疗后再矿化疗法对 WSL 的疗效。
在本系统评价中，作者通过使用与正畸、脱矿和治疗相关的组合搜索词，在 5 个数据库（PubMed、Cochrane 图书馆、Scopus、Embase 和 Web of Science）中确定了列出的相关文章。有 10 篇关于 WSL 再矿化疗法疗效的文章符合纳入标准。
在再矿化治疗的研究中，除了用含氟牙膏进行口腔卫生维护外，氟化物漱口水或含氟和不含氟的磷肽牙膏都没有任何积极作用。5%氟化钠漆是唯一一种与对照组相比显示出统计学显著改善的治疗方法。由于使用的方法不同，作者发现综述研究中的结果存在很大差异。
没有一种治疗方法能够使 WSL 再矿化。5%氟化钠漆可改善 WSL 的再矿化。
