亚硒酸钠对睾丸和前列腺癌细胞中含硒代半胱氨酸的哺乳动物蛋白质基因mRNA表达的影响。
Influence of Sodium Selenite on the mRNA Expression of the Mammalian Selenocysteine-Containing Protein Genes in Testicle and Prostate Cancer Cells.
作者信息
Kuznetsova Yu P, Goltyaev M V, Gorbacheva O S, Novoselov S V, Varlamova E G, Fesenko E E
机构信息
Voronezh State University of Engineering Technology, Voronezh, 394036, Russia.
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia.
出版信息
Dokl Biochem Biophys. 2018 May;480(1):131-134. doi: 10.1134/S1607672918030018. Epub 2018 Jul 14.
The sodium selenite concentration that reduces the viability of Du-145 human prostate adenocarcinoma cells and F-9 mouse testicular teratocarcinoma cells was determined. We investigated the effect of sodium selenite on the mRNA expression level of the genes encoding mammalian selenocysteine-containing glutathione peroxidases and thioredoxin reductases (key antioxidant enzymes involved in the regulation of intracellular thiol redox balance), endoplasmic reticulum selenoproteins, and selenoproteins located in the testes and prostate.
测定了亚硒酸钠降低人Du-145前列腺腺癌细胞和小鼠F-9睾丸畸胎瘤细胞活力的浓度。我们研究了亚硒酸钠对编码含硒代半胱氨酸的哺乳动物谷胱甘肽过氧化物酶和硫氧还蛋白还原酶（参与调节细胞内硫醇氧化还原平衡的关键抗氧化酶）、内质网硒蛋白以及睾丸和前列腺中硒蛋白的基因mRNA表达水平的影响。
Zotero 插件