Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York.
Shoulder, Elbow and Orthopaedic Sports Medicine, Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Ann N Y Acad Sci. 2019 Apr;1442(1):35-47. doi: 10.1111/nyas.13918. Epub 2018 Jul 15.
The rotator cuff is composed of several distinct muscles and tendons that function in concert to coordinate shoulder motion. Injuries to these tendons frequently result in permanent dysfunction and persistent pain. Despite considerable advances in operation techniques, surgical repair alone still does not fully restore rotator cuff function. This review focuses on recent research in the use of biologics and stem cell-based therapies to augment repair, highlighting promising avenues for future work and remaining challenges. While a number of animal models are used for rotator cuff studies, the anatomy of the rotator cuff varies dramatically between species. Since the rodent rotator cuff shares the most anatomical features with the human, this review will focus primarily on rodent models to enable consistent interpretation of outcome measures.
肩袖由几块不同的肌肉和肌腱组成，它们协同作用以协调肩部运动。这些肌腱的损伤常常导致永久性功能障碍和持续疼痛。尽管手术技术有了很大的进步，但仅靠手术修复仍不能完全恢复肩袖的功能。本综述重点介绍了生物制剂和基于干细胞的治疗方法在增强修复方面的最新研究，强调了未来工作的有前景的途径和仍然存在的挑战。虽然有许多动物模型用于肩袖研究，但肩袖的解剖结构在不同物种之间差异很大。由于啮齿动物的肩袖与人类的肩袖具有最相似的解剖特征，因此本综述将主要集中于啮齿动物模型，以实现对结果测量的一致解释。
