Bán Ágnes, Pintér Erika, Kun József
Klinikai Központ, Fogászati és Szájsebészeti Klinika, Parodontológiai Osztály, Pécsi Tudományegyetem, Fogorvos-tudományi Kar Pécs.
Farmakológiai és Farmakoterápiai Intézet, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Szigeti út 12., 7624.
Orv Hetil. 2018 Jul;159(29):1183-1187. doi: 10.1556/650.2018.31088.
Cardiovascular diseases including hypertension affect 40% of the adult population in Hungary. Calcium channel blockers are frequently prescribed for the treatment of hypertension either in monotherapy or in fixed-combination therapy. Their main effect is vasodilatation with gingival hyperplasia as a side effect. Our aim is to draw our colleagues' attention to the practical importance of the fact that calcium channel blocker-induced gingival hyperplasia correlates closely with the dental status and the quantity of plaque on the surface of teeth and dental implants. Once established, gingival hyperplasia makes it more difficult for the patient to maintain individual tooth cleaning and increases plaque formation. Thus proliferation of Gram-negative bacteria is enabled in the plaque which promotes gingival overgrowth and can pose a risk factor for further cardiovascular diseases. If proper individual oral hygiene and professional interventions are carried out, healthy and hyperplasia-free gingival state can be sustained in the long term in most cases, even with calcium channel blocker therapy. In order to protect patients' oral health, a closer cooperation of internists and dentists would be desirable. Orv Hetil. 2018; 159(29): 1183-1187.
包括高血压在内的心血管疾病影响着匈牙利40%的成年人口。钙通道阻滞剂常用于高血压的治疗,可采用单一疗法或固定复方疗法。其主要作用是血管舒张,副作用为牙龈增生。我们的目的是提醒同行注意这样一个事实的实际重要性:钙通道阻滞剂引起的牙龈增生与牙齿及牙种植体表面的牙菌斑状况和数量密切相关。牙龈增生一旦形成,患者就更难保持个人牙齿清洁,并且会增加牙菌斑形成。因此,菌斑中革兰氏阴性菌的增殖会促进牙龈过度生长,并可能成为进一步发生心血管疾病的危险因素。如果进行适当的个人口腔卫生护理和专业干预,即使采用钙通道阻滞剂治疗,在大多数情况下也能长期维持健康且无增生的牙龈状态。为保护患者的口腔健康,内科医生和牙医之间需要更密切的合作。《匈牙利医学周报》。2018年;159(29): 1183 - 1187。