寨卡病毒疫苗：进展与挑战。
Zika Virus Vaccine: Progress and Challenges.
机构信息
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, USA.
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, USA.
出版信息
Cell Host Microbe. 2018 Jul 11;24(1):12-17. doi: 10.1016/j.chom.2018.05.021. Epub 2018 Jun 28.
The explosive emergence of Zika virus has inspired a global effort to develop vaccines. Zika virus, which is a flavivirus primarily transmitted by mosquitoes, can cause devastating congenital syndrome in fetuses of pregnant women, including microcephaly, craniofacial disproportion, spasticity, ocular abnormalities, and miscarriage. In adults, Zika infection has been linked to the autoimmune disorder Guillain-Barré syndrome. Thus, despite the current waning in newly reported Zika infections, an efficacious vaccine is urgently needed to help limit the emergence of another detrimental epidemic. Here we summarize the current status of the Zika vaccine pipeline and highlight the challenges for clinical efficacy trials.
寨卡病毒的爆发引发了全球开发疫苗的努力。寨卡病毒是一种黄病毒，主要通过蚊子传播，可导致孕妇胎儿出现严重的先天性综合征，包括小头畸形、颅面畸形、痉挛、眼部异常和流产。在成年人中，寨卡病毒感染与自身免疫性疾病格林-巴利综合征有关。因此，尽管目前新报告的寨卡病毒感染病例有所减少，但仍迫切需要一种有效的疫苗来帮助限制另一种有害疫情的出现。在这里，我们总结了寨卡病毒疫苗的研发现状，并强调了临床疗效试验所面临的挑战。
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