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葡萄牙急性冠状动脉综合征注册研究(ProACS):15年的连续前瞻性注册研究。

Portuguese Registry of Acute Coronary Syndromes (ProACS): 15 years of a continuous and prospective registry.

作者信息

Timóteo Ana Teresa, Mimoso Jorge

机构信息

Centro Nacional de Coleção de Dados em Cardiologia (CNCDC), Sociedade Portuguesa Cardiologia, Coimbra, Portugal.

Centro Nacional de Coleção de Dados em Cardiologia (CNCDC), Sociedade Portuguesa Cardiologia, Coimbra, Portugal.

出版信息

Rev Port Cardiol (Engl Ed). 2018 Jul;37(7):563-573. doi: 10.1016/j.repc.2017.07.016. Epub 2018 Jun 30.

Abstract

The Portuguese Registry of Acute Coronary Syndromes (ProACS) has completed 15 years of continuous and prospective activity. We present an overall picture of the data from this powerful tool. Up to 2016, 45 141 records were included, mostly male (71%), and with a mean age of 66 years. Baseline characteristics remained stable over the years. Of the overall population, 44% of cases were ST-elevation myocardial infarction (STEMI). Over the years there was a significant improvement in compliance with international guidelines, in terms of both diagnostic and therapeutic procedures, as well as for medication. In particular, the rate of reperfusion in STEMI increased to 84%, mainly by primary percutaneous coronary intervention (only 5.2% were treated by thrombolysis in 2016). By contrast, timings in STEMI did not change significantly. Improvements in treatment were accompanied by a reduction in in-hospital mortality from 6.7% in 2002 to 2.5% in 2016 in the overall population. This registry enables analysis of the management and results of acute coronary syndromes over time in Portugal, and hence assessment of improvements in quality of care.

摘要

葡萄牙急性冠脉综合征注册研究(ProACS)已连续开展前瞻性研究达15年。我们展示了这个强大工具所提供数据的全貌。截至2016年,共纳入45141条记录,其中大多数为男性(71%),平均年龄为66岁。多年来基线特征保持稳定。在总体人群中,44%的病例为ST段抬高型心肌梗死(STEMI)。多年来,在诊断和治疗程序以及用药方面,国际指南的依从性有显著改善。特别是,STEMI的再灌注率升至84%,主要通过直接经皮冠状动脉介入治疗(2016年仅有5.2%接受溶栓治疗)。相比之下,STEMI的治疗时机没有显著变化。治疗的改善伴随着总体人群住院死亡率从2002年的6.7%降至2016年的2.5%。该注册研究有助于分析葡萄牙急性冠脉综合征随时间的管理情况和结果,从而评估医疗质量的改善情况。

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