Nasiri-Amiri Fatemeh, Ramezani Tehrani Fahimeh, Simbar Masoumeh, Montazeri Ali, Mohammadpour Reza Ali
Assistant professor, Department of Midwifery, Babol University of Medical Sciences, Babol, Iran.
Professor, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Endocrinol Metab. 2018 Feb 3;16(2):e12400. doi: 10.5812/ijem.12400. eCollection 2018 Apr.
The health related quality-of-life (HRQoL) among females with polycystic ovary syndrome (PCOS) is reduced due to emotional, psychosocial, infertility, marital, and hirsutism problems.
The current study aimed at analyzing exploratory and confirmatory factor structures of HRQoL questionnaire for polycystic ovary syndrome (PCOSQ-50) in females with PCOS in order to verify the validity of the developed instrument.
The current cross validation study was conducted on females with PCOS using the PCOSQ-50. The PCOSQ-50 was developed based on a qualitative study. The exploratory factor analysis (EFA) and the confirmatory factor analysis (CFA) were conducted to examine the factor structure of PCOSQ-50. After the CFA, the reliability of the new instrument was also evaluated using Cronbach's alpha coefficient.
Totally, 350 females with PCOS were entered into the study. The mean age of the subjects was 26.9 ± 5.1 years. Based on the results of CFA, data were fit to the 43-item model: the comparative fit index (CFI) = 0.91; the normal fit index (NFI) = 0.90; the goodness of fit index (GFI) = 0.60; incremental fit index (IFI) = 0.91; the root mean square error of approximation (RMSEA) = 0.09; standardized root mean square residual (SRMR) = 0.09 and the relative chi-square (x/df) = 2.20, P < 0.05. The intraclass correlation coefficient ranged 0.91 to 0.94 indicating a satisfactory finding.
The 43-item PCOSQ showed appropriate validity and reliability and its psychometric quality was superior to that of the original version. However, further longitudinal studies should be conducted to evaluate its predictive efficacy.
多囊卵巢综合征（PCOS）女性的健康相关生活质量（HRQoL）因情绪、心理社会、不孕、婚姻及多毛问题而降低。
本研究旨在分析多囊卵巢综合征女性HRQoL问卷（PCOSQ - 50）的探索性和验证性因素结构，以验证所开发工具的有效性。
本交叉验证研究使用PCOSQ - 50对PCOS女性进行。PCOSQ - 50是基于一项定性研究开发的。进行探索性因素分析（EFA）和验证性因素分析（CFA）以检验PCOSQ - 50的因素结构。CFA之后，还使用克朗巴哈α系数评估新工具的信度。
共有350名PCOS女性纳入研究。受试者的平均年龄为26.9±5.1岁。基于CFA结果，数据拟合43项模型：比较拟合指数（CFI）=0.91；规范拟合指数（NFI）=0.90；拟合优度指数（GFI）=0.60；增值拟合指数（IFI）=0.91；近似误差均方根（RMSEA）=0.09；标准化残差均方根（SRMR）=0.09；相对卡方值（x/df）=2.20，P<0.05。组内相关系数在0.91至0.94之间，表示结果令人满意。
43项PCOSQ显示出适当的效度和信度，其心理测量质量优于原始版本。然而，应进行进一步的纵向研究以评估其预测效能。
