University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Fertil Steril. 2012 Jan;97(1):225-30.e2. doi: 10.1016/j.fertnstert.2011.10.022. Epub 2011 Nov 27.
To perform a systematic review and meta-analysis of studies that compared the prevalence of anxiety symptoms in women with polycystic ovary syndrome (PCOS) and control women.
Meta-analysis and systematic review.
University practice.
PATIENT(S): Cross-sectional studies comparing PCOS subjects and geographically matched clearly defined non-PCOS control subjects with data on age and body mass index (BMI).
INTERVENTION(S): Anxiety screening tool.
MAIN OUTCOME MEASURE(S): The primary analysis contrasted prevalence of anxiety. Cochrane Review Manager 5.0.24 software was used to construct forest plots comparing frequency of anxiety symptoms in case and control subjects.
RESULT(S): Of 613 screened articles, nine met our selection criteria for a systematic review and four were included in the meta-analysis. The prevalence of generalized anxiety symptoms was available in four studies and was significantly greater in PCOS subjects (42/206, 20.4%) compared to controls (8/204, 3.9%). The odds for anxiety symptoms were significantly greater in women with PCOS compared with control subjects (odds ratio 6.88, 95% confidence interval 2.5-18.9). The mean anxiety score was significantly increased in three of the remaining five studies. Other anxiety disorders, such as social phobia, panic attacks, and obsessive compulsive disorders, were assessed infrequently.
CONCLUSION(S): Our systematic review suggests an increased odds of anxiety symptoms in women with PCOS, underscoring the importance of screening all women with PCOS for anxiety symptoms. Follow-up evaluation and treatment are essential, because generalized anxiety disorder is a chronic condition. Potential contributors for anxiety symptoms, such as hirsutism, obesity, and/or infertility may be specific to women with PCOS but need further investigation.
系统评价和荟萃分析比较多囊卵巢综合征（PCOS）女性和对照女性焦虑症状患病率的研究。
荟萃分析和系统评价。
大学实践。
比较 PCOS 受试者和地理上匹配的明确定义的非 PCOS 对照受试者的横断面研究，这些研究有关于年龄和体重指数（BMI）的数据。
焦虑筛查工具。
主要分析对比了焦虑的患病率。使用 Cochrane Review Manager 5.0.24 软件构建森林图，比较病例组和对照组中焦虑症状的频率。
在 613 篇筛选的文章中，有 9 篇符合我们的系统评价选择标准，有 4 篇被纳入荟萃分析。有 4 项研究提供了广泛性焦虑症状的患病率，PCOS 受试者（42/206，20.4%）明显高于对照组（8/204，3.9%）。与对照组相比，PCOS 女性发生焦虑症状的几率明显更高（比值比 6.88，95%置信区间 2.5-18.9）。其余五项研究中的三项研究中，焦虑评分明显升高。其他焦虑障碍，如社交恐惧症、惊恐发作和强迫症，评估较少。
我们的系统评价表明，PCOS 女性发生焦虑症状的几率增加，这强调了对所有 PCOS 女性进行焦虑症状筛查的重要性。随访评估和治疗至关重要，因为广泛性焦虑症是一种慢性疾病。焦虑症状的潜在诱因，如多毛症、肥胖症和/或不孕症，可能特定于 PCOS 女性，但需要进一步研究。
