发热性中性粒细胞减少患者的念珠菌血症；简要报告
Candidemia in Febrile Neutropenic Patients; a Brief Report.
作者信息
Yousefi Maysam, Yadegarynia Davood, Lotfali Ensieh, Arab-Mazar Zahra, Ghajari Ali, Fatemi Alireza
机构信息
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medial Sciences, Tehran, Iran.
Assistant professor of infectious diseases, Research Center of tropical and infectious diseases, Kerman University of medical sciences, Kerman, Iran.
出版信息
Emerg (Tehran). 2018;6(1):e39. Epub 2018 Jun 19.
INTRODUCTION
Febrile neutropenic patients are at risk of serious infections. The aim of the present study is to identify the frequency, species, and susceptibility patterns of candidemia in febrile neutropenic patients.
METHODS
This cross-sectional study was conducted on febrile neutropenic patients suspected with candidemia who had been referred to 3 educational hospitals during 9 months.
RESULTS
The blood samples of 80 febrile neutropenic patients with the mean age of 48±16.6 years were studied (60% female). Five (6.25%) episodes of candidemia were identified. The underlying disease was acute myeloid leukemia in 4 (80%) cases and all 5(100%) cases had central venous catheter and were receiving prophylactic ciprofloxacin and acyclovir. 100% of isolates were found to be susceptible to Voriconazole, 80% to Caspofungin, 60% to Amphotericin B, and 40% to Fluconazole.
CONCLUSION
The frequency of candidemia among the studied febrile neutropenia patients was 6.25%, with 80% mortality rate, and the most frequently identified yeast was Candida albicans (100% susceptible to Voriconazole).
引言
发热性中性粒细胞减少患者有发生严重感染的风险。本研究的目的是确定发热性中性粒细胞减少患者念珠菌血症的发生率、菌种及药敏模式。
方法
本横断面研究对9个月期间转诊至3家教学医院的疑似念珠菌血症的发热性中性粒细胞减少患者进行。
结果
研究了80例平均年龄为48±16.6岁的发热性中性粒细胞减少患者的血样（60%为女性）。确定了5例（6.25%）念珠菌血症病例。4例（80%）的基础疾病为急性髓系白血病，所有5例（100%）均有中心静脉导管，并接受预防性环丙沙星和阿昔洛韦治疗。发现100%的分离株对伏立康唑敏感，80%对卡泊芬净敏感，60%对两性霉素B敏感，40%对氟康唑敏感。
结论
在所研究的发热性中性粒细胞减少患者中，念珠菌血症的发生率为6.25%，死亡率为80%，最常鉴定出的酵母菌为白色念珠菌（对伏立康唑100%敏感）。
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