卟啉类化合物及相关大环化合物：将光敏化作用与放射或光学成像相结合，用于下一代治疗诊断试剂。
Porphyrins and related macrocycles: Combining photosensitization with radio- or optical-imaging for next generation theranostic agents.
机构信息
School of Mathematics and Physical Sciences, Faculty of Science and Engineering, University of Hull, Hull, UK; Positron Emission Tomography Centre, University of Hull, Hull, UK.
Department of Biotechnology, University of Rijeka, Rijeka, Croatia.
出版信息
Photodiagnosis Photodyn Ther. 2018 Sep;23:281-294. doi: 10.1016/j.pdpdt.2018.06.023. Epub 2018 Jul 29.
This review summarises recent research into combining the photosensitizing properties of porphyrins with imaging techniques such as PET and NIR fluorescence for so called "theranostic" applications, which combine biomedical imaging and therapeutic potential into a single administered substance. The photophysical mechanisms of both the therapeutic and diagnostic properties of porphyrins are discussed, as well as key characteristics that are required in order to deliver the most effective treatment.
本文综述了最近将卟啉的光敏特性与 PET 和近红外荧光等成像技术相结合用于所谓的“治疗诊断学”应用的研究，这种应用将生物医学成像和治疗潜力结合到单一给药物质中。讨论了卟啉的治疗和诊断特性的光物理机制，以及为了提供最有效的治疗所需的关键特性。
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