Rolstad B
Transplantation. 1976 Feb;21(2):117-23. doi: 10.1097/00007890-197602000-00005.
I have measured the proportion of host cells in a popliteal lymph node undergoing a graft-versus-host (GVH) reaction. By using cytotoxic alloantisera with specificity for donor and host Ag-B determined antigens, it was found that about 90% of live cells suspended from the node were of host origin. The role of host T lymphocytes in this reaction was evaluated by investigating GVH-reactivity in hosts depleted of T cells (B rats). These rats differed very little from normal hosts with regard to lymph node weight increase (which was, in fact, slightly enhanced), increase in node cellularity, and donor/host contribution. The number of i.v. infused 51Cr-labelled thoracic duct lymphocytes localizing in popliteal lymph nodes undergoing a GVH-reaction was increased, but the significance of this phenomenon for the lymph node enlargement is questionable.
我已测量了在发生移植物抗宿主（GVH）反应的腘淋巴结中宿主细胞的比例。通过使用对供体和宿主Ag - B确定抗原具有特异性的细胞毒性同种异体抗血清，发现从该淋巴结中悬浮的活细胞约90%来源于宿主。通过研究T细胞耗竭的宿主（B大鼠）中的GVH反应性，评估了宿主T淋巴细胞在该反应中的作用。这些大鼠在淋巴结重量增加（实际上略有增强）、淋巴结细胞增多以及供体/宿主贡献方面与正常宿主差异很小。静脉注射的51Cr标记的胸导管淋巴细胞定位于发生GVH反应的腘淋巴结中的数量增加了，但这种现象对淋巴结肿大的意义值得怀疑。
