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一名患有严重心肌炎和骨骼肌炎的年轻男性。

A Young Male with Severe Myocarditis and Skeletal Muscle Myositis.

作者信息

Ibrahim Abdalla, Meagher Eoghan, Fraser Alexander, Kiernan Thomas J

机构信息

Cardiology Department, University Hospital Limerick, St. Nessan's Road, Dooradoyle, Limerick, Ireland.

Rheumatology Department, University Hospital Limerick, St Nessan's Road, Dooradoyle, Limerick, Ireland.

出版信息

Case Rep Cardiol. 2018 Jun 14;2018:5698739. doi: 10.1155/2018/5698739. eCollection 2018.

Abstract

A 34-year-old male presented with retrosternal chest pain, fatigue, shortness of breath, and a history of a previous episode of myocarditis four years prior. He had elevated troponin T, normal skeletal muscle enzymes, and negative inflammatory markers. Cardiac magnetic resonance imaging (MRI) confirmed active myocarditis with extensive myocardial fibrosis and normal left ventricular ejection fraction (LVEF). His myocarditis symptoms resolved with steroids and anti-inflammatory treatment, but on closer questioning, he reported a vague history of long-standing calf discomfort associated with episodes of stiffness, fatigue, and flu-like symptoms. MRI of the lower legs consequently demonstrated active myositis in the calf muscles. Immunomodulatory therapy was commenced with good effect. The patient is undergoing regular follow-up in both cardiology and rheumatology outpatient departments. Repeated MRI of the legs showed significant interval improvement in his skeletal muscle myositis, and repeat cardiac MRI demonstrated the resolution of myocarditis along with persistent stable extensive myocardial fibrosis and preserved LVEF. The patient has returned to full-time work.

摘要

一名34岁男性出现胸骨后胸痛、疲劳、呼吸急促,并有4年前曾患心肌炎的病史。他的肌钙蛋白T升高,骨骼肌酶正常,炎症标志物阴性。心脏磁共振成像(MRI)证实为活动性心肌炎,伴有广泛心肌纤维化,左心室射血分数(LVEF)正常。他的心肌炎症状经类固醇和抗炎治疗后缓解,但进一步询问时,他报告有长期小腿不适的模糊病史,伴有僵硬、疲劳和流感样症状发作。小腿MRI显示小腿肌肉有活动性肌炎。开始免疫调节治疗,效果良好。该患者正在心脏病学和风湿病学门诊定期随访。腿部重复MRI显示其骨骼肌肌炎有明显的间隔期改善,重复心脏MRI显示心肌炎消退,同时持续存在稳定的广泛心肌纤维化且LVEF保留。该患者已恢复全职工作。

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