Emerg Infect Dis. 2018 Aug;24(8):1422-7. doi: 10.3201/eid2408.180057.
Since the first identification of neonatal microcephaly cases associated with congenital Zika virus infection in Brazil in 2015, a distinctive constellation of clinical features of congenital Zika syndrome has been described. Fetal brain disruption sequence is hypothesized to underlie the devastating effects of the virus on the central nervous system. However, little is known about the effects of congenital Zika virus infection on the peripheral nervous system. We describe a series of 4 cases of right unilateral diaphragmatic paralysis in infants with congenital Zika syndrome suggesting peripheral nervous system involvement and Zika virus as a unique congenital infectious cause of this finding. All the patients described also had arthrogryposis (including talipes equinovarus) and died from complications related to progressive respiratory failure.
自 2015 年巴西首次发现与先天性寨卡病毒感染相关的新生儿小头畸形病例以来，已描述了先天性寨卡综合征的一系列独特临床特征。胎儿脑破坏序列被假设为该病毒对中枢神经系统产生破坏性影响的基础。然而，对于先天性寨卡病毒感染对周围神经系统的影响知之甚少。我们描述了 4 例先天性寨卡综合征婴儿右侧单侧膈肌麻痹的病例，提示周围神经系统受累和寨卡病毒是导致这种发现的独特先天性感染原因。所描述的所有患者还都有关节挛缩（包括马蹄内翻足），并死于与进行性呼吸衰竭相关的并发症。
