肌干细胞支持小组：肌肉再生中的协调细胞反应。
A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration.
机构信息
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.
出版信息
Dev Cell. 2018 Jul 16;46(2):135-143. doi: 10.1016/j.devcel.2018.06.018.
Skeletal muscle has an extraordinary regenerative capacity due to the activity of tissue-specific muscle stem cells. Consequently, these cells have received the most attention in studies investigating the cellular processes of skeletal muscle regeneration. However, efficient capacity to rebuild this tissue also depends on additional cells in the local milieu, as disrupting their normal contributions often leads to incomplete regeneration. Here, we review these additional cells that contribute to the regenerative process. Understanding the complex interactions between and among these cell populations has the potential to lead to therapies that will help promote normal skeletal muscle regeneration under conditions in which this process is suboptimal.
骨骼肌具有非凡的再生能力，这要归功于组织特异性肌肉干细胞的活性。因此，在研究骨骼肌再生的细胞过程中，这些细胞受到了最多的关注。然而，有效地重建这种组织还依赖于局部环境中的其他细胞，因为破坏它们的正常贡献常常导致不完全再生。在这里，我们回顾了这些有助于再生过程的其他细胞。了解这些细胞群体之间以及相互之间的复杂相互作用，有可能导致治疗方法的出现，以帮助促进在这个过程不理想的情况下正常的骨骼肌再生。
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