Microbiology Department and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Microbiology Department and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Immunity. 2018 Jul 17;49(1):4-6. doi: 10.1016/j.immuni.2018.06.015.
The intestinal immune system performs a tightrope walk between anti-pathogen immunity and tolerance to innocuous luminal antigens. In this issue of Immunity, Kim et al. (2018) demonstrate that the microbiota is driving tolerance to food antigens and dampening inflammatory responses through CXCR1 mononuclear phagocytes.
肠道免疫系统在抗病原体免疫和对无害腔抗原的耐受性之间保持着微妙的平衡。在本期《免疫》杂志中，Kim 等人（2018 年）证明了微生物群通过 CXCR1 单核吞噬细胞促进食物抗原的耐受，并抑制炎症反应。
