Uma Devi P, Surana M
Acta Radiol Oncol. 1985 Sep-Oct;24(5):427-31. doi: 10.3109/02841868509134413.
Adult Swiss albino mice were exposed to whole body gamma irradiation with 1.5, 3.0, 6.0 and 9.0 Gy in the presence or absence of the protective drugs MPG and WR-2721. The changes in the total cell population, pyknotic nuclei and necrotic cells, and binucleate cells were observed at various post-irradiation times. The degree of damage increased with the radiation dose. The number of total cells decreased with a corresponding increase in pyknotic nuclei, necrotic cells and binucleate cells. Both drugs provided protection against radiation injury, and reduced early post-irradiation cell damage and enhanced recovery after sublethal exposures. After higher doses, especially after lethal doses, the drugs became less effective in protecting the tissue.
成年瑞士白化小鼠在有或没有保护药物MPG和WR - 2721的情况下，接受1.5、3.0、6.0和9.0 Gy的全身γ射线照射。在照射后的不同时间观察总细胞群体、固缩核和坏死细胞以及双核细胞的变化。损伤程度随辐射剂量增加而增加。总细胞数量减少，同时固缩核、坏死细胞和双核细胞数量相应增加。两种药物均能提供抗辐射损伤保护，减少照射后早期细胞损伤，并增强亚致死照射后的恢复。在较高剂量，尤其是致死剂量后，药物对组织的保护作用减弱。
