Wang Shu-Dong, Ma Qian, Wang Ke, Chen Hong-Wu
Jiangsu Research and Development Center of the Ecological Textile Engineering and Technology, School of Textile and Clothing, Yancheng Polytechnic College, Yancheng 224005, P. R. China.
ACS Omega. 2018 Jan 31;3(1):406-413. doi: 10.1021/acsomega.7b01210. Epub 2018 Jan 12.
In this article, the silk fibroin (SF)/graphene oxide (GO)-blended nanofibers with one bioinspired nanostructure are fabricated via electrospinning. The morphology, chemical structure, antibacterial activity, and biocompatibility of the blending nanofibers are investigated. The results indicate that GO plays an important role in preparing the distinctive bioinspired structure. The antibacterial activity and in vivo cell culture test demonstrate that blending of GO could improve the antibacterial activity and biocompatibility of SF nanofibers. The blended nanofibers developed in this study may have considerable potential for wound dressing applications.
在本文中，通过静电纺丝制备了具有一种仿生纳米结构的丝素蛋白（SF）/氧化石墨烯（GO）共混纳米纤维。研究了共混纳米纤维的形态、化学结构、抗菌活性和生物相容性。结果表明，GO在制备独特的仿生结构中起重要作用。抗菌活性和体内细胞培养试验表明，GO的共混可以提高SF纳米纤维的抗菌活性和生物相容性。本研究中开发的共混纳米纤维在伤口敷料应用方面可能具有相当大的潜力。
