Shapiro L A, Farkas T G
Arch Ophthalmol. 1977 Mar;95(3):456-8. doi: 10.1001/archopht.1977.04450030098013.
A case of lipid keratopathy occurred following acute rupture of Descemet membrane. The cause of the hydrops remained undetermined. There was no history of any prior corneal inflammation or vascularization in the initially involved eye. Lipid deposition was observed following resolution of the corneal edema, and its course was followed for the next several months. Histopathologic studies of the specimen showed lipid deposits in the posterior and middle corneal stroma and degenerative changes in the corneal lamellae and Bruch membrane. Laboratory examination disclosed a type IV hyperlipemia, with normal serum cholesterol levels and elevation of pre-beta-lipoproteins and triglycerides. It cannot be determined from our study if this condition was a causative factor.
1例脂质角膜病变发生于后弹力层急性破裂后。角膜水肿的病因仍未明确。最初受累眼无任何先前角膜炎症或血管化病史。角膜水肿消退后观察到脂质沉积，并在接下来的几个月里对其病程进行了追踪。标本的组织病理学研究显示角膜后基质和中基质中有脂质沉积，角膜板层和布鲁赫膜有退行性改变。实验室检查发现IV型高脂血症，血清胆固醇水平正常，前β脂蛋白和甘油三酯升高。从我们的研究中无法确定这种情况是否为致病因素。
