Clinical Immunology Laboratory, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, United States.
Clinical Immunology Laboratory, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, United States.
J Reprod Immunol. 2018 Sep;129:53-58. doi: 10.1016/j.jri.2018.06.029. Epub 2018 Jun 30.
Preterm birth which occurs before 37 weeks gestation is one of the most common obstetrical complication in humans. After many studies, it appears that "not one answer fits all" regarding the risk factors, causes and the treatments for this syndrome. However, it is becoming more evident that one of the major risk factors is inflammation and/or infection in the fetoplacental unit. In animal models (usually consisting of mice injected with lipopolysaccharide at 14 days of gestation), IL-22 and IL-6 have been identified as factors related to preterm birth. There are some clinical tests available to determine the risk for preterm labor and delivery, which can be identified before, during early, or at mid-gestation. However, treatment of preterm birth with antibiotics so far has not been "curable" and studies using anti-inflammatory treatments are not readily available. More studies regarding causes and treatments for preterm labor and delivery in humans are necessary to prevent neonatal deaths and/or developmental abnormalities associated with this common syndrome.
早产是指妊娠 37 周前分娩，是人类最常见的产科并发症之一。经过多项研究，该综合征的危险因素、病因和治疗方法似乎“并非一因一果”。然而，越来越明显的是，主要危险因素之一是胎盘中的炎症和/或感染。在动物模型（通常由在妊娠 14 天向小鼠注射脂多糖制成）中，IL-22 和 IL-6 已被确定为与早产相关的因素。目前有一些临床测试可用于确定早产的风险，这些测试可以在妊娠早期、中期或晚期之前、期间或之后进行。然而，迄今为止，抗生素治疗早产尚未“治愈”，并且抗炎治疗的研究尚不可用。需要更多关于人类早产和分娩原因和治疗的研究，以预防与这种常见综合征相关的新生儿死亡和/或发育异常。
