Kim J S, Kim D, Joo Y B, Won S, Lee J, Shin J, Bae S-C
1 Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.
2 Department of Rheumatology, St Vincent's Hospital, Catholic University of Korea, Suwon, Republic of Korea.
Lupus. 2018 Oct;27(11):1769-1777. doi: 10.1177/0961203318788163. Epub 2018 Jul 20.
Objectives This study aims to identify the factors associated with the development and mortality of pulmonary hypertension (PH) in systemic lupus erythematosus (SLE) patients. Methods We conducted a prospective study of SLE patients in a single tertiary center. PH was defined as a systolic pulmonary arterial pressure ≥30 mmHg on transthoracic echocardiography. We assessed potential associated factors contributing to the development and mortality of PH in SLE patients. Results Of 1110 patients with SLE, 48 patients were identified to have PH. Multivariable analysis indicated that pleuritis or pericarditis (odds ratio (OR) = 4.62), anti-RNP antibody (OR = 2.42), interstitial lung disease (ILD) (OR = 8.34) and cerebro-cardiovascular disease (OR = 13.37) were independently associated with the development of PH in SLE. Subgroup analysis among patients with PH demonstrated that there were no statistically significant factors associated with PH mortality in SLE. Conclusions The prevalence of PH was 4.3% in our cohort. There were significant associations with pleuritis or pericarditis, anti-RNP antibody, ILD, and cerebro-cardiovascular disease in SLE, which may contribute to the development of PH. However, there were no statistically significant factors associated with PH mortality in SLE.
目的 本研究旨在确定系统性红斑狼疮（SLE）患者肺动脉高压（PH）发生及死亡的相关因素。方法 我们在一个单一的三级中心对SLE患者进行了一项前瞻性研究。PH定义为经胸超声心动图测得的收缩期肺动脉压≥30 mmHg。我们评估了导致SLE患者PH发生及死亡的潜在相关因素。结果 在1110例SLE患者中，48例被确定患有PH。多变量分析表明，胸膜炎或心包炎（比值比（OR）=4.62）、抗RNP抗体（OR =2.42）、间质性肺疾病（ILD）（OR =8.34）和心脑血管疾病（OR =13.37）与SLE患者PH的发生独立相关。PH患者的亚组分析表明，SLE中与PH死亡率相关的因素无统计学意义。结论 在我们的队列中，PH的患病率为4.3%。SLE中胸膜炎或心包炎、抗RNP抗体、ILD和心脑血管疾病之间存在显著关联，这可能导致PH的发生。然而，SLE中与PH死亡率相关的因素无统计学意义。
