Kennedy H, Bullier J, Dehay C
Exp Brain Res. 1985;61(1):204-9. doi: 10.1007/BF00235636.
The laminar location of cytochrome oxidase staining has been compared in the lateral geniculate nucleus and area 17 in newborn and adult macaque monkeys. In area 17 of the adult, the distribution of cytochrome oxidase activity confirmed published findings. In the newborn animals, the tissue reacted as strongly for cytochrome oxidase as in the adult but the pattern of labelling was different in two respects. Firstly in layer 1 activity was stronger and occupied a wider portion of this layer. Secondly, cytochrome oxidase staining in layer 4C occupied two separate bands, a small narrow band at the bottom of 4C beta and a wider one occupying the full width of 4C alpha and spilling over into 4B. The pattern of cytochrome oxidase activity did not appear to be influenced by eccentricity in the newborn whereas, in the adult, label in 4C was more intense in cortex subserving central vision. In the lateral geniculate nucleus of the adult, the magnocellular layers and the most dorsal parvocellular layer reacted most strongly for cytochrome oxidase. In the newborn, parvocellular layers were more uniformly labelled and the difference between parvo- and magnocellular layers more pronounced. These results are discussed in relationship to the development of thalamo-cortical projections in the monkey.
已对新生猕猴和成年猕猴外侧膝状体核及17区细胞色素氧化酶染色的分层位置进行了比较。在成年猕猴的17区，细胞色素氧化酶活性的分布证实了已发表的研究结果。在新生动物中，组织对细胞色素氧化酶的反应与成年动物一样强烈，但标记模式在两个方面有所不同。首先，在第1层活性更强，占据该层更宽的部分。其次，4C层的细胞色素氧化酶染色占据两条分开的带，一条小的窄带位于4Cβ底部，另一条较宽的带占据4Cα的全宽并延伸至4B。新生动物中细胞色素氧化酶活性模式似乎不受偏心度影响，而在成年动物中，4C层的标记在服务于中央视觉的皮层中更强。在成年猕猴的外侧膝状体核中，大细胞层和最背侧的小细胞层对细胞色素氧化酶反应最强。在新生动物中，小细胞层标记更均匀，小细胞层和大细胞层之间的差异更明显。结合猕猴丘脑-皮层投射的发育对这些结果进行了讨论。
