Imani Nima, Shams Shams Aldin, Radfar Moloud, Ghavami Haleh, Khalkhali Hamid Reza
Department of Nursing and Midwifery, Urmia University of Medical Sciences, Urmıa, Iran.
Agri. 2018 Jul;30(3):116-122. doi: 10.5505/agri.2018.43815.
Nitroglycerin (NTG)-induced migraine-type headache is the most prominent side effect of nitrate therapy. Therefore, the aim of this study was to clarify the effectiveness of reflexology massage on intravenous NTG-induced headache in coronary care unit (CCU) inpatients.
This was a randomized clinical trial. The study sample included 75 patients that were randomly divided into three groups: control, intervention, and placebo groups. The intensity of baseline headache in patients who received NTG was measured by the numeric rating scale for pain (NRS Pain). Patients in the intervention group received reflexology massage two times for 20 min (at 3-h interval), wherein the upper part of patient's both foot thumbs, which is the reflection point of the head, was massaged. In the placebo group, an unspecified point on the foot (heel), which was not related to the head, was massaged. Patients in the control group did not receive any massage.
No baseline differences existed among the three groups for the mean pain scale score (p=0.66) before the study; but the difference between the groups after the application was statistically significant (p=0.000).
Reflexology massage can reduce the intensity of NTG-induced headache.
硝酸甘油（NTG）诱发的偏头痛样头痛是硝酸盐治疗最突出的副作用。因此，本研究的目的是阐明反射疗法按摩对冠心病监护病房（CCU）住院患者静脉注射NTG诱发头痛的有效性。
这是一项随机临床试验。研究样本包括75名患者，他们被随机分为三组：对照组、干预组和安慰剂组。接受NTG治疗的患者的基线头痛强度通过疼痛数字评定量表（NRS疼痛量表）进行测量。干预组患者接受两次反射疗法按摩，每次20分钟（间隔3小时），按摩患者双脚拇指上部，即头部的反射点。在安慰剂组中，按摩足部一个与头部无关的未指定点（脚跟）。对照组患者不接受任何按摩。
研究前，三组的平均疼痛量表评分无基线差异（p=0.66）；但应用后组间差异具有统计学意义（p=0.000）。
反射疗法按摩可降低NTG诱发头痛的强度。
