College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Ministry of Education Laboratory of Animal Production and Quality Security, Jilin Agricultural University, Changchun, 130118, China.
Biol Trace Elem Res. 2019 May;189(1):233-240. doi: 10.1007/s12011-018-1447-2. Epub 2018 Jul 21.
Lead (Pb) is one of the most ubiquitous and toxic elements in the aquatic environment. Bacillus subtilis (B. subtilis) is a widely used probiotic in aquaculture. The aim of this study was to explore the toxic effects on bioaccumulation, hematological parameters, and antioxidant responses of Carassius auratus gibelio (C. gibelio) exposed to dietary lead at 0, 120, and 240 mg/kg and/or B. subtilis at 10 cfu/g. At 15 and 30 days, the fish were sampled and bioaccumulation, hematological parameters, and antioxidant responses were assessed. The result showed that B. subtilis administration can provide a significant protection against lead toxicity by reducing lead bioaccumulation in tissues, increasing the antioxidant enzymes activity, recovering δ-aminolevulinic acid dehydratase activity and optimizing the hematological parameters. Our results suggested that administration of B. subtilis (109 cfu/g) has the potential to combat dietary lead toxicity in C. gibelio.
铅（Pb）是水生环境中最普遍存在和毒性最大的元素之一。枯草芽孢杆菌（B. subtilis）是水产养殖中广泛使用的益生菌。本研究旨在探讨日粮铅（0、120 和 240mg/kg）和/或枯草芽孢杆菌（10cfu/g）对吉富罗非鱼（C. gibelio）生物蓄积、血液学参数和抗氧化反应的毒性影响。在第 15 天和第 30 天取样，评估生物蓄积、血液学参数和抗氧化反应。结果表明，枯草芽孢杆菌的添加可以通过降低组织中的铅蓄积、提高抗氧化酶的活性、恢复δ-氨基酮戊酸脱水酶的活性和优化血液学参数，为铅毒性提供显著的保护作用。本研究结果表明，枯草芽孢杆菌（109cfu/g）的添加具有对抗吉富罗非鱼日粮铅毒性的潜力。
