Willard C, Wong E, Hess J F, Shen C K, Chapman B, Wilson A C, Schmid C W
J Mol Evol. 1985;22(4):309-15. doi: 10.1007/BF02115686.
The DNA base sequences of the entire chimpanzee zeta 1 globin gene and an additional 1 kb of DNA flanking both the human and chimpanzee genes have been determined. Whereas the human zeta 1 gene contains a termination codon in the sixth position, the chimpanzee gene appears to be functional. This finding confirms Proudfoot et al.'s suggestion that the human zeta 1 gene was recently inactivated. Like the corresponding human zeta 1 and zeta 2 genes, the first and second introns of the chimpanzee zeta 1 gene are occupied largely by tandem repeats of short oligonucleotides. These tandem repeats have undergone several rearrangements since the divergence of the human and chimpanzee zeta 1 genes.
已经确定了整个黑猩猩ζ1珠蛋白基因的DNA碱基序列以及人类和黑猩猩基因两侧各1 kb的额外DNA。人类ζ1基因在第六位含有一个终止密码子，而黑猩猩基因似乎是有功能的。这一发现证实了普劳德富特等人的观点，即人类ζ1基因最近失活了。与相应的人类ζ1和ζ2基因一样，黑猩猩ζ1基因的第一和第二内含子主要由短寡核苷酸的串联重复序列占据。自从人类和黑猩猩ζ1基因分化以来，这些串联重复序列已经经历了几次重排。
