Liepe Knut, Becker Andreas
Department of Nuclear Medicine, Klinikum Frankfurt (Oder), 15236 Frankfurt (Oder), Germany.
Department of Internal Medicine Gastroenterology, Klinikum Frankfurt (Oder), 15236 Frankfurt (Oder), Germany.
World J Nucl Med. 2018 Jul-Sep;17(3):151-156. doi: 10.4103/wjnm.WJNM_41_17.
The aim of this study was to assess the potential of Tc-Hynic-TOC imaging in the primary diagnosis and follow-up of midgut neuroendocrine tumors (NETs). In comparison to In-octreotide, Tc-Hynic-TOC has a higher imaging quality and leads to a lower radiation absorption in patients. Tc-Hynic-TOC was used for assessing primary diagnosis ( = 14) and during follow-up ( = 17) in patients with NETs. The scintigraphic findings were compared with computed tomography scans and follow-up. In 31 patients, 34 somatostatin receptor scans using 99mTc-Hynic-TOC were performed. The primary diagnoses were midgut NET. The scintigraphy was true positive in 17 patients, true negative in 9, false negative in 4, and false positive in 1. From these data, a sensitivity of 81%, specificity of 90%, positive predictive value of 94%, and negative predictive value of 69% were calculated. In summary, Tc-TOC represents a useful radiotracer in imaging SSTR-expressing tumor lesions with slightly higher sensitivity, higher imaging quality, and lower radiation exposure for patients compared to In-octreotide. A 1-day double-acquisition protocol should be used to reduce false-positive findings of the gut.
本研究的目的是评估锝[99mTc]标记的海因尼克-酪蛋白（Tc-Hynic-TOC）显像在中肠神经内分泌肿瘤（NETs）的初步诊断及随访中的应用潜力。与铟[111In]奥曲肽相比，Tc-Hynic-TOC具有更高的显像质量，且患者的辐射吸收更低。Tc-Hynic-TOC用于评估NETs患者的初步诊断（n = 14）及随访（n = 17）。将闪烁显像结果与计算机断层扫描及随访结果进行比较。对31例患者进行了34次使用99mTc-Hynic-TOC的生长抑素受体扫描。初步诊断为中肠NET。闪烁显像结果为真阳性17例，真阴性9例，假阴性4例，假阳性1例。根据这些数据，计算出灵敏度为81%，特异性为90%，阳性预测值为94%，阴性预测值为69%。总之，与铟[111In]奥曲肽相比，Tc-TOC是一种用于显像表达生长抑素受体（SSTR）的肿瘤病灶的有用放射性示踪剂，其灵敏度略高、显像质量更高，且患者辐射暴露更低。应采用1天双采协议以减少肠道假阳性结果。
