Hanna Violette Said, Hafez Ebtisam Abdel Aziz
Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
J Adv Res. 2018 Mar 13;11:23-32. doi: 10.1016/j.jare.2018.03.005. eCollection 2018 May.
Arachidonic acid (AA), a 20 carbon chain polyunsaturated fatty acid with 4 double bonds, is an integral constituent of biological cell membrane, conferring it with fluidity and flexibility. The four double bonds of AA predispose it to oxygenation that leads to a plethora of metabolites of considerable importance for the proper function of the immune system, promotion of allergies and inflammation, resolving of inflammation, mood, and appetite. The present review presents an illustrated synopsis of AA metabolism, corroborating the instrumental importance of AA derivatives for health and well-being. It provides a comprehensive outline on AA metabolic pathways, enzymes and signaling cascades, in order to develop new perspectives in disease treatment and diagnosis.
花生四烯酸（AA）是一种含有4个双键的20碳链多不饱和脂肪酸，是生物细胞膜的重要组成部分，赋予细胞膜流动性和柔韧性。AA的4个双键使其易于发生氧化反应，从而产生大量对免疫系统正常功能、过敏和炎症的促进、炎症的消退、情绪及食欲具有重要意义的代谢产物。本综述展示了AA代谢的图文概要，证实了AA衍生物对健康和幸福的重要作用。它提供了关于AA代谢途径、酶和信号级联反应的全面概述，以便为疾病治疗和诊断开辟新的视角。
