壳聚糖吡唑基希夫碱的合成：抗菌活性评价。
Synthesis of pyrazole-based Schiff bases of Chitosan: Evaluation of antimicrobial activity.
机构信息
Department of Post-Graduate Studies & Research in Chemistry, Mangalore University, Mangalagangothri, 574199 DK, Karnataka, India.
Department of Post-Graduate Studies & Research in Chemistry, Mangalore University, Mangalagangothri, 574199 DK, Karnataka, India.
出版信息
Int J Biol Macromol. 2018 Nov;119:446-452. doi: 10.1016/j.ijbiomac.2018.07.129. Epub 2018 Jul 21.
In this work, a novel series of Schiff base has been reported by the reaction of Chitosan with different substituted pyrazole-4-carbaldehydes in acidic media. The synthesized compounds were characterized by Fourier-transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), X-ray diffraction (XRD) and C NMR techniques. Chitosan and the Schiff bases were compared for their antimicrobial activity against the bacteria; Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli and a fungi, Candida albicans. The results indicated stronger inhibitory effect of the Schiff bases on these microorganisms compared to Chitosan and the extent of inhibition varied with the nature of substitution.
在这项工作中，壳聚糖与不同取代的吡唑-4-甲醛在酸性介质中反应，生成了一系列新型的席夫碱。合成的化合物通过傅里叶变换红外光谱（FTIR）、热重分析（TGA）、X 射线衍射（XRD）和 C 核磁共振技术进行了表征。壳聚糖和席夫碱的抗菌活性进行了比较，测试了它们对细菌（金黄色葡萄球菌、枯草芽孢杆菌、肺炎克雷伯菌、大肠杆菌）和真菌（白色念珠菌）的抑制作用。结果表明，与壳聚糖相比，席夫碱对这些微生物具有更强的抑制作用，抑制程度随取代基的性质而变化。
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