Instituto de Química, Universidade Federal do Mato Grosso do Sul, Campo Grande, 79074-460, MS, Brazil.
Instituto de Química, Universidade Federal de Goiás - UFG, Goiânia, 74690-900, GO, Brazil.
Curr Med Chem. 2024;31(17):2330-2344. doi: 10.2174/0929867330666230224092830.
Schiff bases represent a valuable class of organic compounds, synthesized via condensation of primary amines with ketones or aldehydes. They are renowned for possessing innumerable applications in agricultural chemistry, organic synthesis, chemical and biological sensing, coating, polymer and resin industries, catalysis, coordination chemistry, and drug designing. Schiff bases contain imine or azomethine (-C=N-) functional groups which are important pharmacophores for the design and synthesis of lead bioactive compounds. In medicinal chemistry, Schiff bases have attracted immense attention due to their diverse biological activities. This review aims to encompass the recent developments on the antimicrobial activities of Schiff bases. The article summarizes the antibacterial, antifungal, antiviral, antimalarial, and antileishmanial activities of Schiff bases reported since 2011.
席夫碱是一类重要的有机化合物，通过伯胺与酮或醛的缩合反应合成。它们在农业化学、有机合成、化学和生物传感、涂料、聚合物和树脂工业、催化、配位化学和药物设计等领域具有广泛的应用。席夫碱含有亚胺或甲亚胺（-C=N-）官能团，这些官能团是设计和合成先导生物活性化合物的重要药效团。在药物化学中，席夫碱因其多种生物活性而受到广泛关注。本综述旨在概述席夫碱的最新抗菌活性研究进展。本文总结了自 2011 年以来报道的席夫碱的抗细菌、抗真菌、抗病毒、抗疟原虫和抗利什曼原虫活性。
