Tian Xiaoru, Zhang Yi
Department of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Zhongguo Fei Ai Za Zhi. 2018 Jul 20;21(7):560-564. doi: 10.3779/j.issn.1009-3419.2018.07.10.
Lung cancer (LC) is the most common cancer and the leading cause of cancer-related death worldwide. The 5-year survival rate for LC remains low at 18% and is 5% for patients with metastatic disease, while the 5-year overall survival rate of patients with stage I NSCLC can reach 77.9%, hence early diagnosis and treatment of LC is the key to improve the prognosis. As a non-invasive detection technique, Raman spectroscopy can realize the non-destructive detection of the differences in molecular level structure between cancerous tissues and normal tissues, which can be used for the early diagnosis of lung cancer. The aim of this review is to summarize the progress of Raman spectroscopycombined with different tissue or body fluid samplesin the diagnosis of early LC. .
肺癌（LC）是全球最常见的癌症，也是癌症相关死亡的主要原因。肺癌的5年生存率仍然很低，仅为18%，而转移性疾病患者的5年生存率为5%，而I期非小细胞肺癌患者的5年总生存率可达77.9%，因此肺癌的早期诊断和治疗是改善预后的关键。作为一种非侵入性检测技术，拉曼光谱可以实现对癌组织和正常组织之间分子水平结构差异的无损检测，可用于肺癌的早期诊断。本综述的目的是总结拉曼光谱结合不同组织或体液样本在早期肺癌诊断中的研究进展。
