1 Département de réadaptation, Faculté de médecine, Université Laval, Quebec City, Quebec, Canada.
2 Centre de recherche CERVO, CERVO Brain Research Center, Quebec City, Quebec, Canada.
Am J Alzheimers Dis Other Demen. 2019 Feb;34(1):5-15. doi: 10.1177/1533317518790541. Epub 2018 Jul 24.
The detection of cognitive impairment in individuals with subjective cognitive decline (SCD) may improve detection of the emergence of Alzheimer's disease (AD) pathology. This detection is challenging, however, given the lack of sensitive assessment tools. The main objective of this study was to determine the potential contribution of word production tasks to the detection of cognitive impairment in SCD. The performances of 20 individuals with SCD, healthy controls (HCs), and individuals with mild cognitive impairment (MCI) were compared on object and action naming and free fluency tasks. Participants with SCD performed similarly to HCs, while both groups differed significantly from participants with MCI in object naming and object fluency. Results showed that participants with SCD were at the midpoint between HCs and participants with MCI in action naming. They also revealed a HCs > SCD = MCI pattern in action fluency. This study provides evidence that verb production is impaired in SCD and that SCD is a pre-MCI condition.
主观认知下降（SCD）个体的认知障碍检测可能有助于发现阿尔茨海默病（AD）病理。然而，由于缺乏敏感的评估工具，这一检测具有挑战性。本研究的主要目的是确定词汇产生任务对 SCD 认知障碍检测的潜在贡献。对 20 名 SCD 患者、健康对照组（HCs）和轻度认知障碍（MCI）患者进行了物体命名、动作命名和自由流畅性任务的比较。SCD 患者的表现与 HCs 相似，而两组在物体命名和物体流畅性方面与 MCI 患者有显著差异。结果表明，SCD 患者在动作命名方面处于 HCs 和 MCI 患者的中间位置。在动作流畅性方面也呈现出 HCs>SCD=MCI 的模式。本研究提供了证据表明，动词产生在 SCD 中受损，SCD 是一种介于 MCI 前的状态。
