Koppara Alexander, Wagner Michael, Lange Carolin, Ernst Annette, Wiese Birgitt, König Hans-Helmut, Brettschneider Christian, Riedel-Heller Steffi, Luppa Melanie, Weyerer Siegfried, Werle Jochen, Bickel Horst, Mösch Edelgard, Pentzek Michael, Fuchs Angela, Wolfsgruber Steffen, Beauducel André, Scherer Martin, Maier Wolfgang, Jessen Frank
Department of Psychiatry and Psychotherapy, Rheinische-Friedrich-Wilhelms University, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Alzheimers Dement (Amst). 2015 May 2;1(2):194-205. doi: 10.1016/j.dadm.2015.02.005. eCollection 2015 Jun.
Our objectives were (1) to test the association between the report of subjective cognitive decline (SCD) and prospective objective cognitive performance in high age individuals and (2) to study the course of longitudinal cognitive performance before and after the first report of SCD.
Cognitively normal elderly participants of the German Study on Ageing, Cognition, and Dementia study (N = 2330) with SCD (subjective decline in memory with and without associated concerns) and without SCD at baseline were assessed over 8 years with regard to immediate and delayed verbal recall, verbal fluency, working memory, and global cognition. Baseline performance and cognitive trajectories were compared between groups. In addition, cognitive trajectories before and after the initial report of SCD (incident SCD) were modelled in those without SCD at baseline.
Baseline performance in the SCD group was lower and declined more steeply in immediate and delayed verbal recall than in the control group (no SCD at baseline). This effect was more pronounced in the SCD group with concerns. Incident SCD was preceded by decline in immediate and delayed memory and word fluency.
SCD predicts future memory decline. Incident SCD is related to previous cognitive decline. The latter finding supports the concept of SCD indicating first subtle decline in cognitive performance that characterizes preclinical Alzheimer's disease.
我们的目标是（1）测试高龄个体主观认知衰退（SCD）报告与前瞻性客观认知表现之间的关联，以及（2）研究首次报告SCD之前和之后纵向认知表现的过程。
德国老龄化、认知与痴呆研究中认知正常的老年参与者（N = 2330），基线时存在SCD（伴有或不伴有相关担忧的主观记忆衰退）和不存在SCD的参与者，在8年时间里接受了即时和延迟言语回忆、言语流畅性、工作记忆和整体认知方面的评估。对两组之间的基线表现和认知轨迹进行了比较。此外，对基线时不存在SCD的参与者中首次报告SCD（新发SCD）之前和之后的认知轨迹进行了建模。
SCD组的基线表现较低，即时和延迟言语回忆方面的衰退比对照组（基线时无SCD）更陡峭。这种效应在伴有担忧的SCD组中更为明显。新发SCD之前即时和延迟记忆以及单词流畅性出现衰退。
SCD可预测未来记忆衰退。新发SCD与先前的认知衰退有关。后一发现支持了SCD这一概念，即表明认知表现首次出现细微衰退，这是临床前阿尔茨海默病的特征。
