Institute of Biomedical Problems RAS, Moscow, Russian Federation.
Specialized Multidisciplinary Hospital №1 of Ukrainian Ministry of Health, Dnipro, Ukraine.
CNS Neurol Disord Drug Targets. 2018;17(8):604-607. doi: 10.2174/1871527317666180726095734.
It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice.
Determine the role of gamma-synuclein inactivation on memory performance in aging animals.
We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice.
As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained.
Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory.
先前的研究表明，小而可溶性的神经元蛋白γ-突触核蛋白的失活会影响敲除小鼠的心理情绪状态和认知能力。
确定γ-突触核蛋白失活对衰老动物记忆表现的影响。
我们使用被动回避测试和急性安非他命给药来研究衰老的γ-突触核蛋白敲除小鼠。
我们发现，衰老与γ-突触核蛋白敲除小鼠的多巴胺能神经递质系统中度无关的缺陷。同时，获得了突触小泡转运机制进行性损伤的证据。
因此，这些功能障碍很可能与需要完整工作记忆的测试中高效学习表现的降低有关。
