自闭症谱系障碍中 Alpha 和 Gamma 突触核蛋白的血浆水平：严重程度的指标。
Plasma Levels of Alpha and Gamma Synucleins in Autism Spectrum Disorder: An Indicator of Severity.
机构信息
Department of Physiology, Faculty of Medicine, Imam Mohammed bin Saud Islamic University, Riyadh, Saudi Arabia,
Autism Research & Treatment Center, Al-Amodi Autism Research Chair, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.
出版信息
Med Princ Pract. 2021;30(2):160-167. doi: 10.1159/000513935. Epub 2020 Dec 21.
OBJECTIVES
The aim of this study was to correlate plasma levels of the synaptic proteins α-synuclein and γ-synuclein in autism spectrum disorder (ASD) children in order to elucidate their possible contribution to the pathogenesis of ASD and to study their association with the severity of the disorder.
SUBJECTS AND METHODS
Plasma levels of α-synuclein and γ-synuclein were measured in 38 male children diagnosed with ASD and 40 healthy age-matched male children by ELISA.
RESULTS
Our results showed that plasma levels of α-synuclein (18.02 ± 5.3 pg/mL) were significantly higher in ASD children than in control children (14.39 ± 2 pg/mL), and plasma levels of γ-synuclein were decreased in the ASD group (23.74 ± 7.7 pg/mL) compared to the control group (32.40 ± 6.8 pg/mL) (p < 0.0001). Our data also indicate that plasma levels of both α-synuclein and γ-synuclein are significantly associated with the severity of ASD.
CONCLUSIONS
Our study showed that alteration in α-synuclein and γ-synuclein might be associated with ASD pathogenesis and could be an indicator of the severity of the disorder.
目的
本研究旨在探讨自闭症谱系障碍（ASD）患儿血浆中突触蛋白α-突触核蛋白和γ-突触核蛋白的水平，以阐明其对 ASD 发病机制的可能贡献，并研究其与疾病严重程度的关系。
对象和方法
采用 ELISA 法检测 38 名男性 ASD 患儿和 40 名年龄匹配的健康男性儿童的血浆α-突触核蛋白和γ-突触核蛋白水平。
结果
我们的结果表明，ASD 患儿血浆α-突触核蛋白水平（18.02±5.3 pg/mL）明显高于对照组（14.39±2 pg/mL），而 ASD 组γ-突触核蛋白水平（23.74±7.7 pg/mL）低于对照组（32.40±6.8 pg/mL）（p<0.0001）。我们的数据还表明，血浆中α-突触核蛋白和γ-突触核蛋白的水平与 ASD 的严重程度显著相关。
结论
本研究表明，α-突触核蛋白和γ-突触核蛋白的改变可能与 ASD 的发病机制有关，并且可能是疾病严重程度的一个指标。
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