L2C豚鼠淋巴细胞上低密度脂蛋白（LDL）和转铁蛋白受体内化效率的比较。

Comparison of the internalization efficiency of LDL and transferrin receptors on L2C guinea pig lymphocytes.

作者信息

Vidal M, Sainte-Marie J, Philippot J R, Bienvenue A

出版信息

FEBS Lett. 1986 Feb 17;196(2):242-6. doi: 10.1016/0014-5793(86)80255-1.

Abstract

We demonstrate that L2C lymphocytes have about 10-times more receptors for transferrin (Tf) than healthy lymphocytes, as has been shown in the case of LDL receptors. The dissociation constant is the same in the two cell types (about 4 X 10(-7) M). In contrast to LDL, Tf enters L2C lymphocytes with very rapid kinetics. It is shown by cross-reaction that each receptor is internalized independently of the other.

摘要

我们证明，L2C淋巴细胞转铁蛋白（Tf）受体的数量约为健康淋巴细胞的10倍，低密度脂蛋白（LDL）受体的情况也是如此。两种细胞类型的解离常数相同（约4×10⁻⁷M）。与LDL不同，Tf以非常快的动力学进入L2C淋巴细胞。交叉反应表明，每个受体都是独立内化的。