Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Adv Exp Med Biol. 2018;1119:119-131. doi: 10.1007/5584_2018_251.
Wound healing is a complex process with the considerable burden on healthcare system. There are several cellular therapy methods that have been introduced to treat different types of wounds. Despite the advantages of cellular therapy, it is needed to overcome different limitations of this method such as; tumorigenicity and immune rejection. Accordingly, scientists have suggested cell-based vesicles and exosomes. Exosomes can promote proliferation, migration, and angiogenesis process in the wound environment. They have also some advantages such as the potential for drug and gene delivery, easy to storage, and stability in the body. These advantages make them as a novel approach in regenerative medicine without the limitations of cellular therapy. In this review, the authors emphasize on biological properties of MSC-exosomes and their therapeutic effects as a new strategy for wound regeneration.
伤口愈合是一个复杂的过程，给医疗系统带来了相当大的负担。有几种细胞治疗方法已经被引入来治疗不同类型的伤口。尽管细胞治疗有很多优点，但仍需要克服该方法的一些局限性，如致瘤性和免疫排斥。因此，科学家们提出了基于细胞的囊泡和外泌体。外泌体可以促进伤口环境中的增殖、迁移和血管生成过程。它们还具有一些优点，如药物和基因传递的潜力、易于储存和在体内的稳定性。这些优点使它们成为再生医学的一种新方法，没有细胞治疗的局限性。在这篇综述中，作者强调了 MSC-exosomes 的生物学特性及其作为伤口再生新策略的治疗效果。
