Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.
Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY, USA.
Nat Rev Genet. 2018 Oct;19(10):615-634. doi: 10.1038/s41576-018-0034-x.
RNA performs and regulates a diverse range of cellular processes, with new functional roles being uncovered at a rapid pace. Interest is growing in how these functions are linked to RNA structures that form in the complex cellular environment. A growing suite of technologies that use advances in RNA structural probes, high-throughput sequencing and new computational approaches to interrogate RNA structure at unprecedented throughput are beginning to provide insights into RNA structures at new spatial, temporal and cellular scales.
RNA 执行和调节多种细胞过程，新的功能角色正在迅速被揭示。人们越来越关注这些功能如何与在复杂细胞环境中形成的 RNA 结构相关联。越来越多的技术套件利用 RNA 结构探针、高通量测序和新的计算方法的进步，以前所未有的通量来研究 RNA 结构，开始为新的空间、时间和细胞尺度的 RNA 结构提供深入了解。
