神经调节的新视角。
A dLight-ful New View of Neuromodulation.
机构信息
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
出版信息
Trends Neurosci. 2018 Sep;41(9):566-568. doi: 10.1016/j.tins.2018.07.004. Epub 2018 Jul 25.
Abstract
Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.
摘要
神经调质如多巴胺可以改变神经回路的功能，但这种转变的机制尚不完全清楚。最近的一项研究引入了 dLight1，这是一种基因编码的荧光多巴胺指示剂。dLight1 允许以高时空分辨率对隔离的目标回路感知的多巴胺进行光学测量，并且在研究神经调质机制方面具有独特的优势。
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