Bervoets Liene, Massa Guy, Guedens Wanda, Reekmans Gunter, Noben Jean-Paul, Adriaensens Peter
Faculty of Medicine & Life Sciences, Hasselt University, Martelarenlaan 42, 3500 Hasselt, Belgium.
Department of Pediatrics, Jessa Hospital, Stadsomvaart 11, 3500 Hasselt, Belgium.
Future Sci OA. 2018 May 23;4(6):FSO310. doi: 10.4155/fsoa-2017-0146. eCollection 2018 Jul.
To identify the plasma metabolic profile associated with childhood obesity and its metabolic phenotypes.
MATERIALS & METHODS: The plasma metabolic profile of 65 obese and 37 normal-weight children was obtained using proton NMR spectroscopy. NMR spectra were rationally divided into 110 integration regions, which reflect relative metabolite concentrations, and were used as statistical variables.
Obese children show increased levels of lipids, N-acetyl glycoproteins, and lactate, and decreased levels of several amino acids, α-ketoglutarate, glucose, citrate, and cholinated phospholipids as compared with normal-weight children. Metabolically healthy children show lower levels of lipids and lactate, and higher levels of several amino acids and cholinated phospholipids, as compared with unhealthy children.
This study reveals new valuable findings in the field of metabolomics and childhood obesity. Although validation should be performed, the proof of principle looks promising and justifies a deeper investigation of the diagnostic possibilities of proton NMR metabolomics in follow-up studies. NCT03014856. Registered January 9, 2017.
确定与儿童肥胖及其代谢表型相关的血浆代谢谱。
采用质子核磁共振波谱法获取65名肥胖儿童和37名正常体重儿童的血浆代谢谱。核磁共振谱被合理地划分为110个积分区域，这些区域反映相对代谢物浓度，并用作统计变量。
与正常体重儿童相比，肥胖儿童的脂质、N - 乙酰糖蛋白和乳酸水平升高，几种氨基酸、α - 酮戊二酸、葡萄糖、柠檬酸和胆碱磷脂水平降低。与代谢不健康的儿童相比，代谢健康的儿童脂质和乳酸水平较低，几种氨基酸和胆碱磷脂水平较高。
本研究在代谢组学和儿童肥胖领域揭示了新的有价值的发现。尽管应进行验证，但原理证明看起来很有前景，有理由在后续研究中对质子核磁共振代谢组学诊断可能性进行更深入的研究。NCT03014856。于2017年1月9日注册。
