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miR-370-3p 和 miR-495-3p 作为脓毒症相关性急性肾损伤生物标志物的潜力。

The Potential of miR-370-3p and miR-495-3p Serving as Biomarkers for Sepsis-Associated Acute Kidney Injury.

机构信息

Department of Nephrology, SINOPHARM North Hospital, Baotou, 014030 Inner Mongolia, China.

出版信息

Comput Math Methods Med. 2022 Jul 11;2022:2439509. doi: 10.1155/2022/2439509. eCollection 2022.

DOI:10.1155/2022/2439509
PMID:35860182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9293507/
Abstract

OBJECTIVE

This study is aimed at evaluating the miR-370-3p and miR-495-3p expression in the urine of patients with sepsis-associated acute kidney injury (SA-AKI) and exploring its diagnosis value in for SA-AKI.

METHODS

184 sepsis invalids were collected and divided two groups (non-AKI group or AKI group) according to whether they had acute kidney injury. RT-qPCR was utilized to measure miR-370-3p and miR-495-3p expressions. ROC curve was performed to evaluate the diagnostic value of miR-370-3p and miR-495-3p for SA-AKI. Patients diagnosed with SA-AKI were followed up for 28 days to record survival time. The prognostic performance of miR-370-3p and miR-495-3p for SA-AKI was evaluated by survival curves.

RESULTS

Compared with non-AKI invalids, miR-370-3p and miR-495-3p expressions were obviously lower in the urine of AKI invalids. miR-370-3p and miR-495-3p expressions were markedly negatively correlated with biomarkers of renal injury. Furthermore, the area under the curve (AUC) of miR-370-3p and miR-495-3p for diagnosing sepsis SA-AKI was 0.896 and 0.814, respectively. The higher 28 days-survival rate was observed in patients with high miR-370-3p and miR-495-3p expressions.

CONCLUSIONS

A novel biomarker for the early diagnosis of SA-AKI may be miR-370-3p and miR-495-3p, which was clearly reduced in the urine of SA-AKI patients.

摘要

目的

本研究旨在评估脓毒症相关性急性肾损伤（SA-AKI）患者尿液中 miR-370-3p 和 miR-495-3p 的表达情况，并探讨其在 SA-AKI 诊断中的价值。

方法

收集 184 例脓毒症患者，根据是否发生急性肾损伤分为非 AKI 组或 AKI 组。利用 RT-qPCR 测量 miR-370-3p 和 miR-495-3p 的表达。绘制 ROC 曲线评估 miR-370-3p 和 miR-495-3p 对 SA-AKI 的诊断价值。对诊断为 SA-AKI 的患者进行 28 天随访，记录生存时间。通过生存曲线评估 miR-370-3p 和 miR-495-3p 对 SA-AKI 的预后性能。

结果

与非 AKI 患者相比，AKI 患者尿液中 miR-370-3p 和 miR-495-3p 的表达明显降低。miR-370-3p 和 miR-495-3p 的表达与肾损伤标志物呈明显负相关。此外，miR-370-3p 和 miR-495-3p 诊断脓毒症 SA-AKI 的曲线下面积（AUC）分别为 0.896 和 0.814。miR-370-3p 和 miR-495-3p 表达较高的患者 28 天生存率较高。

结论

miR-370-3p 和 miR-495-3p 可能是 SA-AKI 的早期诊断的新型生物标志物，在 SA-AKI 患者的尿液中明显降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d281/9293507/f8166a1e9ef0/CMMM2022-2439509.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d281/9293507/ccabe4157d69/CMMM2022-2439509.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d281/9293507/93f5628c5c54/CMMM2022-2439509.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d281/9293507/f8166a1e9ef0/CMMM2022-2439509.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d281/9293507/ccabe4157d69/CMMM2022-2439509.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d281/9293507/93f5628c5c54/CMMM2022-2439509.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d281/9293507/f8166a1e9ef0/CMMM2022-2439509.003.jpg

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