Li Shulin, Hu Wanru, Qian Luoxiang, Sun Dong
Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Central Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Mol Cell Biochem. 2025 Mar;480(3):1287-1304. doi: 10.1007/s11010-024-05083-0. Epub 2024 Aug 7.
Noncoding RNAs (ncRNAs) have emerged as pivotal regulators of gene expression, and have attracted significant attention because of their various roles in biological processes. These molecules have transcriptional activity despite their inability to encode proteins. Moreover, research has revealed that ncRNAs, especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), are linked to pervasive regulators of kidney disease, including anti-inflammatory, antiapoptotic, antifibrotic, and proangiogenic actions in acute and chronic kidney disease. Although the exact therapeutic mechanism of ncRNAs remains uncertain, their value in treatment has been studied in clinical trials. The numerous renal diseases and the beneficial or harmful effects of NcRNAs on the kidney will be discussed in this article. Afterward, exploring the biological characteristics of ncRNAs, as well as their purpose and potential contributions to acute and chronic renal disease, were explored. This may offer guidance for treating both acute and long-term kidney illnesses, as well as insights into the potential use of these indicators as kidney disease biomarkers.
非编码RNA（ncRNAs）已成为基因表达的关键调节因子，并因其在生物过程中的多种作用而备受关注。尽管这些分子无法编码蛋白质，但它们具有转录活性。此外，研究表明，ncRNAs，尤其是微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs），与肾脏疾病的广泛调节因子有关，包括在急性和慢性肾脏疾病中的抗炎、抗凋亡、抗纤维化和促血管生成作用。尽管ncRNAs的确切治疗机制仍不确定，但它们在治疗中的价值已在临床试验中得到研究。本文将讨论众多肾脏疾病以及ncRNAs对肾脏的有益或有害影响。随后，探讨了ncRNAs的生物学特性，以及它们对急性和慢性肾脏疾病的作用和潜在贡献。这可能为治疗急性和长期肾脏疾病提供指导，并为这些指标作为肾脏疾病生物标志物的潜在用途提供见解。
