Department of Public Health, China Medical University, Taichung, Taiwan, R.O.C.
Brain Disease Research Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.
PLoS One. 2018 Jul 30;13(7):e0201408. doi: 10.1371/journal.pone.0201408. eCollection 2018.
Opioid addiction is a major public health issue worldwide. Methadone maintenance treatment (MMT) is used to detoxify users of illicit opiates, but drug relapse is common and associated with poor quality of life (QoL). This study investigated the associations between the GRIN3A, GRM6, and TPH2 genetic variants and QoL in the MMT population. A total of 319 participants were included in the study, and genotyping of GRIN3A, GRM6, and TPH2 genes was performed using the Sequenom iPLEX. Associations between genotypes and the domains of QoL were examined through posthoc analysis with LSMEANS syntax using SAS 9.1.3. The single nucleotide polymorphisms rs9325202 and rs1487275 in the TPH2 gene were significantly associated with the QoL domain of physical functioning. The least absolute shrinkage and selection operator regression model revealed that the risk allele rs1487275-G was significantly correlated with the domain of physical functioning when clinical characteristics were considered as covariates. The results of the present study illuminate the importance of the genetic basis of QoL in the MMT population, and suggest that genotypes should be considered as a potential QoL indicator.
阿片类药物成瘾是全球范围内的一个主要公共卫生问题。美沙酮维持治疗 (MMT) 用于戒除非法阿片类药物使用者的毒瘾，但药物复吸很常见，且与生活质量 (QoL) 差有关。本研究调查了 GRIN3A、GRM6 和 TPH2 基因变异与 MMT 人群 QoL 之间的关联。共有 319 名参与者纳入研究，使用 Sequenom iPLEX 对 GRIN3A、GRM6 和 TPH2 基因进行基因分型。使用 SAS 9.1.3 通过 LSMEANS 语法进行事后分析，研究了基因型与 QoL 各领域之间的关联。TPH2 基因中的单核苷酸多态性 rs9325202 和 rs1487275 与 QoL 的生理功能领域显著相关。最小绝对收缩和选择算子回归模型表明，在考虑临床特征为协变量时，风险等位基因 rs1487275-G 与生理功能领域显著相关。本研究的结果阐明了 MMT 人群 QoL 的遗传基础的重要性，并表明基因型可作为潜在的 QoL 指标。
