Mason J M, Kitchens G G, Eastham R J, Jennings B R
Arch Otolaryngol. 1977 Apr;103(4):223-7. doi: 10.1001/archotol.1977.00780210079009.
The thymus-dependent lymphocytes (T cells) were enumerated in the peripheral circulation of 38 patients with histologically demonstrated squamous cell carcinoma of the head and neck. We have previously shown that this "total" T-cell count correlates well with degree of tumor involvement. A lower percentage of T cells were shown in patients with more advanced malignant neoplasms. Here we present follow-up data on these patients to evaluate the efficiency of the T-cell test in determining survival prognoses. We found no evidence that results of this test can extend prognostic abilities above those based on clinical staging. The survival data from six patients treated with a chemoimmunotherapy regimen of BCG vaccine, methotrexate sodium, and isoniazid did not demonstrate an increased survival time compared to patients at similar clinical stages who were treated by conventional use of surgery and irradiation.
对38例经组织学证实为头颈部鳞状细胞癌的患者外周循环中的胸腺依赖性淋巴细胞（T细胞）进行了计数。我们之前已经表明，这种“总”T细胞计数与肿瘤累及程度密切相关。恶性肿瘤进展程度越高的患者，其T细胞百分比越低。在此，我们展示这些患者的随访数据，以评估T细胞检测在确定生存预后方面的有效性。我们没有发现证据表明该检测结果能够在基于临床分期的预后能力之上进一步提高预后判断能力。与接受传统手术和放疗的处于相似临床分期的患者相比，接受卡介苗、甲氨蝶呤钠和异烟肼化疗免疫疗法治疗的6例患者的生存数据并未显示出生存时间延长。
