State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Chem Commun (Camb). 2018 Aug 14;54(66):9155-9158. doi: 10.1039/c8cc04621b.
A core-shell nanostructure is fabricated with a pH-sensitive metal-organic framework shell and a peptide functionalized gold nanoparticle core via a mild synthetic route. The nanostructure can be applied as a dual-recognition switch in response to an acidic environment and enzyme activity, sequentially, leading to a stepwise-responsive strategy for imaging lysosomal cathepsin B.
一种核壳纳米结构是通过温和的合成路线制备的，其外壳是一种 pH 敏感的金属有机骨架，内核是肽功能化的金纳米粒子。该纳米结构可以作为双识别开关，依次响应酸性环境和酶活性，从而实现对溶酶体组织蛋白酶 B 的逐步响应成像策略。
