Bali Sumeet K, Madaiah Hemalata, Dharmapalan Jayanthi, Janarthanam Sanghamitra, Tarannum Fouzia
Department of Periodontics, M.R. Ambedkar Dental College and Hospital, Bangalore, Karnataka, India.
J Investig Clin Dent. 2018 Nov;9(4):e12353. doi: 10.1111/jicd.12353. Epub 2018 Jul 30.
In the present study, we evaluated the effect of systemic long-term, low-dose aspirin on the periodontal status and gingival crevicular fluid (GCF) concentrations of aspirin-triggered lipoxins (ATL) and soluble CD14 (sCD14).
The study group consisted of 45 patients who were on long-term, low-dose aspirin therapy, and the control group included patients not on aspirin therapy. Mean bleeding index, plaque index (PI), probing depth (PD), and clinical attachment loss (CAL) were recorded. GCF samples were analyzed for concentrations of ATL, and sCD14 using enzyme-linked immunosorbent assay method.
The means of PI, PD, and CAL were higher for the control group compared to the study group. The mean concentration of ATL was significantly higher for the study group (49.13 ± 37.39 ng/mL). The mean concentration of sCD14 was higher in the control group (5.75 ± 3.91 μg/mL). There was a negative correlation in the study group between concentrations of ATL with PD (r = -0.54) and CAL (r = -0.123). There was a positive correlation between sCD14 and CAL (r = 0.047) in the study group. A negative correlation was also observed between concentrations of sCD14 and ATL (r = -0.134) in the study group.
The results indicate better periodontal status among long-term aspirin users compared to non-aspirin users.
在本研究中，我们评估了全身性长期低剂量阿司匹林对牙周状况以及阿司匹林触发的脂氧素（ATL）和可溶性CD14（sCD14）龈沟液（GCF）浓度的影响。
研究组由45名接受长期低剂量阿司匹林治疗的患者组成，对照组包括未接受阿司匹林治疗的患者。记录平均出血指数、菌斑指数（PI）、探诊深度（PD）和临床附着丧失（CAL）。使用酶联免疫吸附测定法分析GCF样本中ATL和sCD14的浓度。
与研究组相比，对照组的PI、PD和CAL均值更高。研究组中ATL的平均浓度显著更高（49.13±37.39纳克/毫升）。对照组中sCD14的平均浓度更高（5.75±3.91微克/毫升）。在研究组中，ATL浓度与PD（r=-0.54）和CAL（r=-0.123）之间存在负相关。研究组中sCD14与CAL之间存在正相关（r=0.047）。研究组中sCD14浓度与ATL之间也存在负相关（r=-0.134）。
结果表明，与未使用阿司匹林的人相比，长期使用阿司匹林的人牙周状况更好。
