三级护理教学医院抗生素使用模式、手术部位感染的发生率及预测因素
Pattern of antibiotics use, incidence and predictors of surgical site infections in a Tertiary Care Teaching Hospital.
作者信息
Halawi Ezaedin, Assefa Tamrat, Hussen Sadikalmahdi
机构信息
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University College of Health Sciences, P.O.Box:1176, Addis Ababa, Ethiopia.
出版信息
BMC Res Notes. 2018 Jul 31;11(1):538. doi: 10.1186/s13104-018-3643-8.
Abstract
OBJECTIVE
Surgical site infections (SSIs) were the most common healthcare-associated infection mainly in developing countries. Inappropriate use of surgical antibiotic prophylaxis, in terms of antibiotic choice, timing, and duration, can lead to the selection of resistant microorganisms and high costs. The aim of this study was to investigate the pattern of antibiotic use, incidence and predictors of SSIs at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.
RESULTS
From 131 patients, 55.7% were male study participants. Ninety (68.7%) patients received preoperative prophylaxis. Ceftriaxone was the most 76 (84.5%) prescribed agent for prophylaxis. Twenty-seven (20.6%) patients developed surgical site infection. Previous surgery AOR = 3.22 (95% CI [1.14-9.13]) and alcohol use AOR = 7.04 (95% CI [2.56-23.12, p = 0.000]) were independent predictors of SSIs in multivariate logistic regression analysis.
摘要
目的
手术部位感染（SSIs）是主要在发展中国家最常见的医疗相关感染。在手术抗生素预防方面，无论是抗生素的选择、时机还是持续时间不当，都可能导致耐药微生物的产生以及成本增加。本研究的目的是调查埃塞俄比亚亚的斯亚贝巴提库尔·安贝萨专科医院的抗生素使用模式、手术部位感染的发生率及预测因素。
结果
在131名患者中，55.7%为男性研究参与者。90名（68.7%）患者接受了术前预防。头孢曲松是最常用的预防用药，有76名（84.5%）患者使用。27名（20.6%）患者发生了手术部位感染。在多因素逻辑回归分析中，既往手术调整后比值比（AOR）=3.22（95%置信区间[1.14 - 9.13]）和饮酒AOR = 7.04（95%置信区间[2.56 - 23.12]，p = 0.000）是手术部位感染的独立预测因素。
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