Department of Molecular Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA
mBio. 2018 Jul 31;9(4):e00948-18. doi: 10.1128/mBio.00948-18.
This question of whether fungi undergo apoptosis-like programmed cell death can be separated into two questions. One question is about applying the term "apoptosis" to fungi, and the other is a more challenging question of whether fungi have evolved mechanisms that inflict self-injury. The answers to both questions depend on the definitions applied to "apoptosis" and "programmed cell death." Considering how these and other cell death terms originated and are currently defined for animals, some confusion arises when the terms are applied to fungi. While it is difficult to defend the concept of fungal apoptosis, the more interesting issue is whether fungi will eventually be found to encode programmed or extemporaneous self-destructive processes, as suggested by intriguing new findings.
这个关于真菌是否经历类似细胞凋亡的程序性细胞死亡的问题，可以分为两个问题。一个问题是关于将“细胞凋亡”一词应用于真菌，另一个更具挑战性的问题是真菌是否已经进化出了自我伤害的机制。这两个问题的答案都取决于应用于“细胞凋亡”和“程序性细胞死亡”的定义。考虑到这些和其他细胞死亡术语的起源以及目前在动物身上的定义，当这些术语应用于真菌时，会产生一些混淆。虽然很难为真菌细胞凋亡的概念辩护，但更有趣的问题是，真菌是否最终会被发现编码程序性或即兴的自我毁灭过程，正如新出现的有趣发现所暗示的那样。
