Aguiar Stefane A, Baker Stuart N, Gant Katie, Bohorquez Jorge, Thomas Christine K
Institute of Neuroscience, Newcastle University , Newcastle Upon Tyne , United Kingdom.
The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine , Miami, Florida.
J Neurophysiol. 2018 Oct 1;120(4):1765-1771. doi: 10.1152/jn.00112.2018. Epub 2018 Aug 1.
Intermuscular coherence allows the investigation of common input to muscle groups. Although beta-band (15-30 Hz) intermuscular coherence is well understood as originating from the cortex, the source of intermuscular coherence at lower frequencies is still unclear. We used a wearable device that recorded electromyographic (EMG) signals during a 24-h period in four lower limb muscles of seven spinal cord injury patients (American Spinal Cord Injury Association impairment scale: A, 6 subjects; B, 1 subject) while they went about their normal daily life activities. We detected natural spasms occurring during these long-lasting recordings and calculated intermuscular coherence between all six possible combinations of muscle pairs. There was significant intermuscular coherence at low frequencies, between 2 and 13 Hz. The most likely source for this was the spinal cord and its peripheral feedback loops, because the spinal lesions in these patients had interrupted connections to supraspinal structures. This is the first report to demonstrate that the spinal cord is capable of producing low-frequency intermuscular coherence with severely reduced or abolished descending drive. NEW & NOTEWORTHY This is the first report to demonstrate that intermuscular coherence between lower limb muscles at low frequencies can be produced by the spinal cord with severely reduced or abolished descending drive.
肌间相干性有助于研究肌肉群的共同输入。虽然β波段（15 - 30赫兹）的肌间相干性被很好地理解为起源于皮层，但较低频率下肌间相干性的来源仍不清楚。我们使用了一种可穿戴设备，在7名脊髓损伤患者（美国脊髓损伤协会损伤分级：A级，6名受试者；B级，1名受试者）的四条下肢肌肉进行24小时日常生活活动期间记录肌电图（EMG）信号。我们在这些长时间记录过程中检测到自然痉挛，并计算了所有六种可能肌肉对组合之间的肌间相干性。在2至13赫兹的低频范围内存在显著的肌间相干性。其最可能的来源是脊髓及其外周反馈回路，因为这些患者的脊髓损伤中断了与脊髓上结构的连接。这是第一份证明脊髓能够在下行驱动严重减少或消失的情况下产生低频肌间相干性的报告。新发现与值得注意之处 这是第一份证明脊髓能够在下行驱动严重减少或消失的情况下产生下肢肌肉低频肌间相干性的报告。
