a Institute of Materials Science and Technology , Sichuan University , Chengdu , China.
b College of Polymer Science and Engineering , Sichuan University , Chengdu , China.
J Biomater Sci Polym Ed. 2018 Oct;29(15):1825-1838. doi: 10.1080/09205063.2018.1506399. Epub 2018 Sep 29.
Polymeric porous ultrafine fibers with different structures as drug carrier could be facilely prepared. However, the drug release characteristics and relevant mechanism of different structural porous ultrafine fibers were not well studied. In the present work, different structural Poly-Ether-Sulfone (PES) based porous ultrafine fibers, namely PES, PES/Poly-Ethylene-Glycol (PEG) and PES/Water were prepared by electro-spinning. Curcumin was chosen as drug model loaded in these fibers. Investigation of curcumin release characteristics was carried out by the total immersion in buffer solution. The surface and inner structure of PES based ultrafine fibers were studied by scanning electron microscopy (SEM) in detail. It is found that there is significant difference in the accumulate release amount and release rate with similar structure. About 92.5% of curcumin released within 600 min for PES/PEG ultrafine fibers and only 58.9% of curcumin flowed out from PES with 1000 min. In order to discuss the fact of this phenomenon, the development structure of PES based porous ultrafine fibers was studied with curcumin release. The results indicated that the curcumin release was directly involved with the structure. For PES/PEG, curcumin around the surface layer released in advance. And then, some penetrable structure emerged with PEG dissolving in the buffer solution, which result in larger specific surface area and more embedded curcumin from the interior structure of the ultrafine fibers diffusing out. For the others, curcumin release only through its own pores of ultrafine fibers. Finally, the processing-structure-performance relationship of PES based porous ultrafine fibers were confirmed by the diversity of porosity and contact angle. The research results demonstrate that PES based porous ultrafine fibers have the potential to be used as drug carrier in the drug delivery according to the practical clinical requirements.
具有不同结构的聚合物多孔超细纤维可作为药物载体轻松制备。然而，不同结构的多孔超细纤维的药物释放特性和相关机制尚未得到很好的研究。在本工作中，通过静电纺丝制备了不同结构的聚醚砜（PES）基多孔超细纤维，即 PES、PES/聚乙二醇（PEG）和 PES/水。选择姜黄素作为负载在这些纤维中的药物模型。通过在缓冲溶液中完全浸泡来研究姜黄素的释放特性。通过扫描电子显微镜（SEM）详细研究了 PES 基超细纤维的表面和内部结构。发现具有相似结构的累积释放量和释放速率有明显差异。对于 PES/PEG 超细纤维，约 92.5%的姜黄素在 600 分钟内释放，而只有 58.9%的姜黄素在 1000 分钟内从 PES 中流出。为了解释这种现象，研究了 PES 基多孔超细纤维的发展结构与姜黄素释放的关系。结果表明，姜黄素的释放直接与结构有关。对于 PES/PEG，表面层周围的姜黄素先释放。然后，一些可渗透的结构出现，PEG 在缓冲溶液中溶解，导致更大的比表面积和更多嵌入的姜黄素从超细纤维的内部结构中扩散出来。对于其他纤维，姜黄素只能通过自身的超细纤维孔释放。最后，通过多孔性和接触角的多样性证实了 PES 基多孔超细纤维的加工-结构-性能关系。研究结果表明，根据实际的临床需求，PES 基多孔超细纤维具有作为药物载体在药物传递中的应用潜力。
